Two long separated half-siblings Bernice (Vice Ganda) and Detty (AiAi Delas Alas) are reunited but on a complete reversal of fortune. Bernice hires Detty as an assistant and makes her life difficult in revenge to a tragic childhood. Detty, unaffected by Bernice's cruelty, helps him to overcome his bitter business rival, Roselle (Kris Aquino). "Sisterakas" is a Filipino comedy from Star Cinema.