Honey (Sharon Cuneta) finds out Tim (John Estrada), her husband of 20 years is cheating on her. To save her marriage, she joins a gym to get into shape in hopes her husband will be physically attracted to her again. At the gym, she befriends Frances (Ai-Ai dela Alas), a fitness instructor who may have an interesting connection to Tim. "BFF: Best Friends Forever" is a Filipino Star Cinema film.