When extremely dangerous spores are found growing and contaminating an elderly woman's (Fiona Hale, Seven Pounds, The Curious Case of Benjamin Button) basement, Dr. Locke (Danny Glover), a prolific military scientist, takes his team to investigate. Led by Renner (Vinnie Jones, X-Men: The Last Stand), the squad quickly realise they have a potential bioweapon on their hands. Meanwhile Dean (Taylor Handley, Texas Chainsaw Massacre: The Beginning), a soldier recently back from conflict, arrives at the house with friends to try and help his grandmother in any way he can. Without realising, they inadvertently become part of a top secret experiment and leaving the contaminated basement is no longer be an option. As time runs out, the infection spreads and the scientists find themselves on the cusp of unleashing Armageddon, it soon becomes a fierce fight to the death.