Cronenberg's first feature for seven years collates a number of key Cronenberg themes, most specifically body fetishism, sexual manipulation, scientific and corporate skulduggery. As the human species adapts to a synthetic environment, the body undergoes new transformations and mutations. With his partner Caprice (Seydoux), Saul Tenser (Mortensen), celebrity performance artist, publicly showcases the metamorphosis of his organs in avant-garde performances. Timlin (Stewart), an investigator from the National Organ Registry, obsessively tracks their movements, which is when a mysterious group is revealed… Their mission - to use Saul's notoriety to shed light on the next phase of human evolution.